Effect of garlic (Allium sativum) on hematology and erythrocyte antioxidant defense system of albino rats exposed to heavy metals (nickel II & chromium VI).

نویسندگان

  • Swati N Tikare
  • Saeed Yendigeri
  • Amrita Das Gupta
  • Salim A Dhundasi
  • Kusal K Das
چکیده

Heavy metals are stable environmental contaminants, causing various alterations in target tissues. Garlic has some beneficial effect in preventing heavy metal induced various alteration. The objective was to investigate the possible protective role of fresh aqueous homogenate of garlic on hematology, erythrocyte antioxidant defense system in male albino rats treated with NiSO4 and K2Cr2O7. Rats were divided into six groups. Group I was untreated control. Group II was given aqueous homogenate of garlic (orally). Group III was administered with nickel sulfate (i.p). Group IV was given NiSO4 and garlic simultaneously. Group V was administered with K2Cr2O7 (i.p). Group VI were treated simultaneously with K2Cr2O7 and garlic. RBC, WBC, platelet count, PCV%, hemoglobin concentration decreased significantly and clotting time increased significantly after nickel treatment. After chromium treatment all the values decreased except clotting time. Increased malondialdehyde and glutathione level after nickel and chromium treatment was observed. Also erythrocyte superoxide dismutase, glutathione peroxidase and catalase activities significantly increased after nickel and chromium treatment. Simultaneous garlic supplementation exhibited protective role to combat nickel toxicity, whereas no such beneficial effects were observed for chromium (VI). Garlic may partially prevent nickel and chromium induced alteration but such ameliorated effects as an antioxidant is only restricted on nickel induced alteration.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effect of Garlic (Allium sativum) on Heavy Metal (Nickel II and ChromiumVI) Induced Alteration of Serum Lipid Profile in Male Albino Rats

We have studied the effect of simultaneous oral treatment of aqueous garlic extract (Allium sativum) on heavy metal (nickel II and chromium VI) induced changes in serum lipid profile. Nickel sulfate and potassium dichromate treated rats showed a significant increase in serum low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDL-C) and triglyceride (TG) leve...

متن کامل

Effects of cell phone radiation on estrogen and progesterone levels and ovarian changes in rats treated with garlic (Allium sativum L.) hydro-alcoholic extract

Background & Aim: Electromagnetic waves can damage sex organs and cause hormonal disorders, whereas garlic is known as reducing risk factors for various diseases. The aim of this study was to investigate the probable effects of mobile phone radiation and consumption of garlic on estrogen and progesterone levels and ovarian changes. Experimental: Five groups of rats (n = 8) were used which grou...

متن کامل

Effects of cell phone radiation on estrogen and progesterone levels and ovarian changes in rats treated with garlic (Allium sativum L.) hydro-alcoholic extract

Background & Aim: Electromagnetic waves can damage sex organs and cause hormonal disorders, whereas garlic is known as reducing risk factors for various diseases. The aim of this study was to investigate the probable effects of mobile phone radiation and consumption of garlic on estrogen and progesterone levels and ovarian changes. Experimental: Five groups of rats (n = 8) were used which grou...

متن کامل

Protective effects of garlic aquous extract (Allium sativum), vitamin E, and N-acetylcysteine on reproductive quality of male rats exposed to lead

The objective of present study was to investigate the effects of aqueous garlic extracts, vitamin E and N-acetylcysteine on lead-induced lipid peroxidation, changes in antioxidant defense system and semen quality in the rat testes. Twenty-five male rats were divided into five groups. Animals within different treatment groups were maintained on their respective diets for 35 days as follows: grou...

متن کامل

P-17: Effects of Garlic (Allium Sativum L), Vitamin E and Cystein on LH and Testosterone Hormone Level Related with Lead Toxicity in The Male Rat

Background: Lead (Pb) is one of the ubiquitous nonessential haevy metals in the environment. There are evidences, which show that lead toxicity has many undesired effects, including neurological, behavioral, immunological, renal, hepatic, male reproductive, dysfunctions. The objective of the present study was to investigate the effects of aqueous garlic extracts, vitamin E and N-Acetylcysteine ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Indian journal of physiology and pharmacology

دوره 56 2  شماره 

صفحات  -

تاریخ انتشار 2012